Neuroinflammation in primary blast neurotrauma: Time course and prevention by torso shielding
نویسندگان
چکیده
منابع مشابه
Scaling in Blast Neurotrauma
The high incidence of blast exposure on today’s battlefield has been strongly associated with traumatic brain injuries. Anecdotal evidence of prolonged apnea following blast exposure has been observed in military personnel and is commonly reproduced in animal neurotrauma models. Animal models have shown that apnea tolerance is both dose and species-dependent; important factors include primary b...
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A majority of investigations on primary blast injuries have focused on gas-containing organs, while the likelihood of blast-induced neurotrauma remains underrated. In Norway minke whales (Balaenoptera acutorostrata) are hunted using small fishing boats rigged with harpoon guns, which fire harpoons tipped with a grenade containing a charge of 30-g penthrite. The grenade detonates 60-70 cm inside...
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Explosive blast traumatic brain injury (TBI) is one of the more serious wounds suffered by United States service members injured in the current conflicts in Iraq and Afghanistan. Some military medical treatments for blast TBI that have been introduced successfully in the war theater include decompressive craniectomy, cerebral angiography, transcranial Doppler, hypertonic resuscitation fluids, a...
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Although advances are being made in identifying some of the essential mechanisms that may lead to chronic neurological deficits after blast-exposure(s), clinical needs continue to exceed current knowledge. In their current article, Brenner and colleagues address the importance of basic science in guiding new diagnostic and treatment strategies. Together with Wilkinson et al., they emphasize one...
متن کاملChronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model.
Blast exposure is associated with traumatic brain injury (TBI), neuropsychiatric symptoms, and long-term cognitive disability. We examined a case series of postmortem brains from U.S. military veterans exposed to blast and/or concussive injury. We found evidence of chronic traumatic encephalopathy (CTE), a tau protein-linked neurodegenerative disease, that was similar to the CTE neuropathology ...
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ژورنال
عنوان ژورنال: Experimental Neurology
سال: 2016
ISSN: 0014-4886
DOI: 10.1016/j.expneurol.2016.01.010